%A  Kaszaki JĂłzsef
%A  PalĂĄsthy Zsolt
%A  Érces Dániel
%A  RĂĄcz A.
%A  Torday Csilla
%A  Varga Gabriella
%A  VĂŠcsei LĂĄszlĂł
%A  Boros MihĂĄly
%N 1
%L publicatio9968
%X Kynurenic acid (KynA), an endogenous antagonist of N-methyl-D-aspartate
(NMDA) glutamate receptors, protects the central nervous system in
excitotoxic neurological diseases. We hypothesized that the inhibition
of enteric glutamate receptors by KynA may influence dysmotility in the
gastrointestinal tract. Group 1 of healthy dogs served as the
sham-operated control, in group 2, the animals were treated with KynA,
while in groups 3 and 4 mechanical colon obstruction was maintained for
7 h. Group 4 was treated with KynA at the onset of ileus. Hemodynamics
and motility changes were monitored, and the activities of xanthine
oxidoreductase (XOR) and myeloperoxidase (MPO) were determined from
tissue samples. Colon obstruction induced a hyperdynamic circulatory
reaction, significantly elevated the motility index and increased the
mucosal leucocyte accumulation and the XOR activity. The KynA treatment
augmented the tone of the colon, permanently decreased the motility
index of the giant colonic contractions and reduced the increases in
XOR and MPO activities. These effects were concomitant with the in
vitroinhibition of XOR activity. In conclusion, KynA antagonizes the
obstruction-induced motility responses and XOR activation in the colon.
Inhibition of enteric NMDA receptors may provide an option to influence
intestinal hypermotility and inflammatory changes.
%T Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs
%D 2008
%J NEUROGASTROENTEROLOGY AND MOTILITY
%P 53-62
%I Wiley-Blackwell Publishing Ltd.
%R 1117035
%V 20
%O FELTÖLTŐ: Gyengéné Ruszka Marian - gyengeneruszka@freemail.hu