relation: http://publicatio.bibl.u-szeged.hu/9929/
title: Effects of Blood Glutamate Scavenging on Cortical Evoked Potentials
creator:  Nagy Dávid
creator:  Knapp Levente
creator:  Marosi Máté Gábor
creator:  Farkas Tamás
creator:  Kis Zsolt
creator:  Vécsei László
creator:  Teichberg Vivian I.
creator:  Toldi József
description: It is well known that traumatic or ischemic brain injury is followed by acute excitotoxicity caused by the presence of abnormally high glutamate (Glu) in brain fluids. It has recently been demonstrated that excess Glu can be eliminated from brain into blood following the intravenous administration of oxaloacetate (OxAc), which, by scavenging blood Glu, induces an enhanced and neuroprotective brain-to-blood Glu efflux. In this study, we subjected rats to intravenous OxAc administration (i.v., 12.5, 25, and 50 mg/kg, respectively), and studied its effects on somatosensory evoked cortical potentials (EPs). Against our expectation, the amplitudes of EPs did not decrease but increased in a dose- and time-dependent manner after OxAc administration. Similar effects were observed when blood Glu scavenging was enhanced by combining OxAc (12.5 mg/kgbw) with recombinant glutamate-oxaloacetate transaminase (GOT, 0.14 nmol/100 g rat). On the basis of these results, we suggest that the changes of amplitudes of the EPs involve not only a glutamatergic but also the weakening of a GABAergic component. We cannot rule out the possibility that OxAc penetrates into the brain and improves mitochondrial functions.
publisher: Springer
date: 2010
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/9929/1/Nagy_D._Effect_of_blood_glut._u.pdf
identifier:     Nagy Dávid;  Knapp Levente;  Marosi Máté Gábor;  Farkas Tamás;  Kis Zsolt;  Vécsei László;  Teichberg Vivian I.;  Toldi József: Effects of Blood Glutamate Scavenging on Cortical Evoked Potentials.   CELLULAR AND MOLECULAR NEUROBIOLOGY, 30 (7).  pp. 1101-1106.  ISSN 0272-4340 (2010)     
identifier: doi:10.1007/s10571-010-9542-8
relation: 1386357
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1007/s10571-010-9542-8
rights: info:eu-repo/semantics/restrictedAccess