TY  - JOUR
SP  - Terjedelem: 8 p.
N1  - FELTÖLT?: Wilhelm Imola Mária - wilhelm@brc.hu
 FELTÖLTÉSI MEGJEGYZÉS: A kiadói fájl (2016 Wilhelm Tissue Barriers heterogeneity review) nem tehet? nyilvánossá.
EP  - Azonosító: e1143544
SN  - 2168-8362
A1  -  Wilhelm Imola Mária
A1  -  Nyúl-Tóth Ádám
A1  -  Suciu Maria
A1  -  Hermenean Anca
A1  -  Krizbai István Adorján
N2  - The brain microvascular network is comprised of capillaries, arterioles and venules, all of which retain - although to a different extent - blood-brain barrier (BBB) properties. Capillaries constitute the largest and tightest microvasculature. In contrast, venules have a looser junctional arrangement, while arterioles have a lower expression of P-gp. Development and maintenance of  the BBB depends on the interaction of cerebral endothelial cells with pericytes and astrocytes, which are all heterogeneous in different regions of the central nervous system. At the level of circumventricular organs microvessels are permeable, containing fenestrations and discontinuous tight junctions. In addition, the blood-spinal cord barrier - where the number of pericytes is lower  and expression of junctional proteins is reduced - is also more permeable than the BBB. However, much less is known about the cellular, molecular and functional differences among other regions of the brain. This review summarizes our current  knowledge on the heterogeneity of the brain microvasculature.
UR  - http://publicatio.bibl.u-szeged.hu/8799/
IS  - 1
Y1  - 2016///
VL  - 4
AV  - restricted
PB  - Landes Bioscience
ID  - publicatio8799
JF  - TISSUE BARRIERS
TI  - Heterogeneity of the blood-brain barrier
ER  -