relation: http://publicatio.bibl.u-szeged.hu/8799/
title: Heterogeneity of the blood-brain barrier
creator:  Wilhelm Imola Mária
creator:  Nyúl-Tóth Ádám
creator:  Suciu Maria
creator:  Hermenean Anca
creator:  Krizbai István Adorján
description: The brain microvascular network is comprised of capillaries, arterioles and venules, all of which retain - although to a different extent - blood-brain barrier (BBB) properties. Capillaries constitute the largest and tightest microvasculature. In contrast, venules have a looser junctional arrangement, while arterioles have a lower expression of P-gp. Development and maintenance of  the BBB depends on the interaction of cerebral endothelial cells with pericytes and astrocytes, which are all heterogeneous in different regions of the central nervous system. At the level of circumventricular organs microvessels are permeable, containing fenestrations and discontinuous tight junctions. In addition, the blood-spinal cord barrier - where the number of pericytes is lower  and expression of junctional proteins is reduced - is also more permeable than the BBB. However, much less is known about the cellular, molecular and functional differences among other regions of the brain. This review summarizes our current  knowledge on the heterogeneity of the brain microvasculature.
publisher: Landes Bioscience
date: 2016
type: Folyóiratcikk
type: NonPeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/8799/1/2016_Tissue_Barriers_review_proof_corrected_u.pdf
format: text
identifier: http://publicatio.bibl.u-szeged.hu/8799/2/2016_Wilhelm_Tissue_Barriers_heterogeneity_review_u.pdf
identifier:     Wilhelm Imola Mária;  Nyúl-Tóth Ádám;  Suciu Maria;  Hermenean Anca;  Krizbai István Adorján: Heterogeneity of the blood-brain barrier.   TISSUE BARRIERS, 4 (1).  Terjedelem: 8 p.-Azonosító: e1143544.  ISSN 2168-8362 (2016)     
identifier: doi:10.1080/21688370.2016.1143544
relation: 3082580
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1080/21688370.2016.1143544
rights: info:eu-repo/semantics/restrictedAccess