relation: http://publicatio.bibl.u-szeged.hu/8318/
title: Syntheses and Antiproliferative Effects of D-homo- and D-secoestrones
creator:  Mernyák Erzsébet
creator:  Szabó Johanna
creator:  Bacsa Ildikó
creator:  Huber Judit
creator:  Schneider Gyula
creator:  Minorics Renáta
creator:  Bózsity Noémi
creator:  Zupkó István
creator:  Varga Mónika
creator:  Bikádi Zsolt
creator:  Hazai Eszter
creator:  Wölfling János
description: Abstract Substituted and/or heterocyclic D-homoestrone derivatives were synthetized via the intramolecular cyclization of a δ-alkenyl-D-secoaldehyde, -D-secoalcohol or -D-secocarboxylic acid of estrone 3-benzyl ether. The D-secoalcohol was modified at three sites in the molecule. The in vitro antiproliferative activities of the new D-homo- and D-secoestrone derivatives were determined on HeLa, MCF-7, A431 and A2780 cells through use of MTT assay. D-Homoalcohols 3 and 5 displayed cell line-selective cytostatic effects against ovarian and cervical cell lines, respectively. Two D-secoestrones (6 and 12c) proved to be effective, with IC50 values comparable with those of the reference agent cisplatin. A selected compound (6) was tested by tubulin polymerization assay and its cancer specificity was additionally determined by using noncancerous human fibroblast cells.
date: 2014
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/8318/1/Steroids_dhomo_seco_u.pdf
identifier:     Mernyák Erzsébet;  Szabó Johanna;  Bacsa Ildikó;  Huber Judit;  Schneider Gyula;  Minorics Renáta;  Bózsity Noémi;  Zupkó István;  Varga Mónika;  Bikádi Zsolt;  Hazai Eszter;  Wölfling János: Syntheses and Antiproliferative Effects of D-homo- and D-secoestrones.   STEROIDS, 87.  pp. 128-136.  ISSN 0039-128X (2014)     
identifier: doi:10.1016/j.steroids.2014.05.015
relation: 2602154
language: eng