relation: http://publicatio.bibl.u-szeged.hu/7523/
title: Optimization of technological parameters using acustic cavitation to reach particle size reduction of pharmacon
creator:  Ambrus Rita
creator:  Bartos Csilla
creator:  Révész Piroska
description: The main aspect in the field of pharmaceutical technology is the preformulation of the poorly water soluble drugs. The habit of particles can effect the physico-chemical properties which are important factors by drug administration. In the past years the role of the procedures by acustic cavitation increased in the field of particle engineering. Application of high power ultrasound by integration and dezintegration can lead to particle size decreasing. Meloxicam as a nonsteroid anti-inflammatory model drug was used to study the effect of power ultrasound on the particle size decreasing. During our work technological parameters, as amplitude, temperature, time, excipients and concentration were optimized based on particle size distribution. Physico-chemical stability tests were also performed (XRPD, DSC, SEM, particle size). With optimized parameters (70% amplitude, 20 min, 47°C) using excipients, crystalline micronized product was produced.
date: 2011
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/7523/1/Eljarasi_parameterek_optimalizalasa_szonikus_kavitacio_alkalmazasaval_hatoanyag_szemcsemeret_csokkentese_celjabol_u.pdf
identifier:     Ambrus Rita;  Bartos Csilla;  Révész Piroska: Optimization of technological parameters using acustic cavitation to reach particle size reduction of pharmacon.   ACTA PHARMACEUTICA HUNGARICA, 81 (2).  pp. 51-58.  ISSN 0001-6659 (2011)     
relation: 1894920
language: hun
relation: info:eu-repo/semantics/altIdentifier/doi/
rights: info:eu-repo/semantics/restrictedAccess