relation: http://publicatio.bibl.u-szeged.hu/6926/
title: Synthesis of novel 17-(5’-iodo)triazolyl-3-methoxyestrane epimers via Cu(I)-catalyzed azide-alkyne cycloadditon, and an evaluation of their cytotoxic activity in vitro
creator:  Schneider Gyula
creator:  Görbe Tamás Ferenc
creator:  Mernyák Erzsébet
creator:  Wölfling János
creator:  Holczbauer Tamás
creator:  Czugler Mátyás
creator:  Sohár Pál
creator:  Minorics Renáta
creator:  Zupkó István
description: Abstract The regioselective Cu(I)-catalyzed 1,3-dipolar cycloaddition of 3-methoxyestrane 17α- and 17β-azide epimers (3 and 5) with different terminal alkynes afforded novel 1,4-substituted triazolyl derivatives (8a-c and 10a-c). If the Ph3P in the classical CuAAC process was repleaced by Et3N, the formation of small quantities of 5-iodotriazoles (9a-c and 11a-c) was observed. For the preparation of 5-iodo-1,2,3-triazoles (9a-c and 11a-c), an improved method was developed, directly from steroidal azides and terminal alkynes, in reactions mediated by CuI and ICl as iodinating agents. The antiproliferative activities of the structurally related triazoles were determined in vitro with the microculture tetrazolium assay on six malignant human cell lines of gynecological origin (HeLa, A2780, MCF7, MB-231, MB-361 and T47D). X-ray analysis revealed the presence of the iodo substituent on the 1,2,3-triazole ring.
date: 2015
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/6926/1/135_Steroids_2015.pdf
identifier:     Schneider Gyula;  Görbe Tamás Ferenc;  Mernyák Erzsébet;  Wölfling János;  Holczbauer Tamás;  Czugler Mátyás;  Sohár Pál;  Minorics Renáta;  Zupkó István: Synthesis of novel 17-(5’-iodo)triazolyl-3-methoxyestrane epimers via Cu(I)-catalyzed azide-alkyne cycloadditon, and an evaluation of their cytotoxic activity in vitro.   STEROIDS, 98.  pp. 153-165.  ISSN 0039-128X (2015)     
identifier: doi:10.1016/j.steroids.2015.02.018
relation: 2851809
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1016/j.steroids.2015.02.018
rights: info:eu-repo/semantics/restrictedAccess