relation: http://publicatio.bibl.u-szeged.hu/36293/
title: IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning
creator:  Hernandez-Resendiz Sauri
creator:  Vilskersts Reinis
creator:  Aluja David
creator:  Andreadou Ioanna
creator:  Bencsik Péter
creator:  Dambrova Maija
creator:  Efentakis Panagiotis
creator:  Gao Fei
creator:  Giricz Zoltán
creator:  Inserte Javier
creator:  Kelly-Laubscher Roisin
creator:  Kiss Attila
creator:  Krieg Thomas
creator:  Kwak Brenda R
creator:  Lecour Sandrine
creator:  Lopaschuk Gary
creator:  Mączewski Michał
creator:  Waszkiewicz Michał
creator:  Oknińska Marta
creator:  Pagliaro Pasquale
creator:  Podesser Bruno
creator:  Prag Hiran A
creator:  Ruiz-Meana Marisol
creator:  Szabados Tamara
creator:  Zuurbier Coert J
creator:  Ferdinandy Péter
creator:  Hausenloy Derek J
subject: 03.02. Klinikai orvostan
description: Although many cardioprotective interventions have been shown to limit infarct size (IS), in preclinical animal studies of acute myocardial ischemia/reperfusion injury (IRI), their clinical translation to patient benefit has been largely disappointing. A major factor is the lack of rigor and reproducibility in the preclinical studies. To address this, we have established the IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) small animal multisite acute myocardial infarction (AMI) network, with centralized randomization and blinded core laboratory IS analysis, and have validated the network using ischemic preconditioning (IPC). Eight sites from the COST Innovators Grant (IG16225) network participated in the IMPACT AMI study. Mice and rats were randomly allocated into Sham, Control, or IPC groups. The IRI group underwent 45 min (mice) or 30 min (rats) of left coronary artery occlusion followed by 24 h reperfusion. IPC comprised three cycles of 5 min occlusion/reperfusion before IRI. IS was determined by a blinded core lab. The majority of site showed significant cardioprotection with IPC. In pooled mouse data, IPC (N = 42) reduced IS/AAR by 35% compared to control (N = 48) (30 ± 16% versus 46 ± 13%; p < 0.005), and in rat data, IPC (N = 36) reduced IS/AAR by 29% when compared to control (N = 39) (32 ± 19% versus 45 ± 14%; p < 0.01). The IMPACT multisite mouse and rat AMI networks, with centralized randomization and blinded core IS analysis, were established to improve the reproducibility of cardioprotective interventions in preclinical studies and to facilitate the translation of these therapies for patient benefit.
date: 2025
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/36293/7/35909240.pdf
format: text
identifier: http://publicatio.bibl.u-szeged.hu/36293/1/Hernandez.pdf
identifier:     Hernandez-Resendiz Sauri;  Vilskersts Reinis;  Aluja David;  Andreadou Ioanna;  Bencsik Péter;  Dambrova Maija;  Efentakis Panagiotis;  Gao Fei;  Giricz Zoltán;  Inserte Javier;  Kelly-Laubscher Roisin;  Kiss Attila;  Krieg Thomas;  Kwak Brenda R;  Lecour Sandrine;  Lopaschuk Gary;  Mączewski Michał;  Waszkiewicz Michał;  Oknińska Marta;  Pagliaro Pasquale;  Podesser Bruno;  Prag Hiran A;  Ruiz-Meana Marisol;  Szabados Tamara;  Zuurbier Coert J;  Ferdinandy Péter;  Hausenloy Derek J: IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning.   BASIC RESEARCH IN CARDIOLOGY, 120.  pp. 335-346.  ISSN 0300-8428 (2025)     
identifier: doi:10.1007/s00395-025-01102-3
relation: https://doi.org/10.1007/s00395-025-01102-3
relation: 35909240
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1007/s00395-025-01102-3
rights: info:eu-repo/semantics/openAccess