TY  - JOUR
Y1  - 2015///
ID  - publicatio35917
A1  -  Gray Diane
A1  -  Willemse Lauren
A1  -  Visagie Ane
A1  -  Smith Emilee
A1  -  Czövek Dorottya
A1  -  Sly Peter D.
A1  -  Hantos Zoltán
A1  -  Hall Graham L.
A1  -  Zar Heather J.
TI  - Lung function and exhaled nitric oxide in healthy unsedated African infants
SP  - 1108
N2  - Background and objective: Population-appropriate lung function reference data are essential to accurately identify respiratory disease and measure response to interventions. There are currently no reference data in African infants. The aim was to describe normal lung function in healthy African infants. Methods: Lung function was performed on healthy South African infants enrolled in a birth cohort study, the Drakenstein child health study. Infants were excluded if they were born preterm or had a history of neonatal respiratory distress or prior respiratory tract infection. Measurements, made during natural sleep, included the forced oscillation technique, tidal breathing, exhaled nitric oxide and multiple breath washout measures. Results: Three hundred sixty-three infants were tested. Acceptable and repeatable measurements were obtained in 356 (98%) and 352 (97%) infants for tidal breathing analysis and exhaled nitric oxide outcomes, 345 (95%) infants for multiple breath washout and 293 of the 333 (88%) infants for the forced oscillation technique. Age, sex and weight-for-age z score were significantly associated with lung function measures. Conclusions: This study provides reference data for unsedated infant lung function in African infants and highlights the importance of using population-specific data.
VL  - 20
N1  - Department of Paediatrics and Child Health, University of Cape Town, Cape Town, 7700, South Africa            
            MRC Unit, Child and Adolescent Lung Health, Cape Town, South Africa            
            Division of Epidemiology and Biostatistics, School of Public Health and Family, University of Cape Town, Cape Town, South Africa            
            Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary            
            Queensland Children's Medical Research Institute, University of Queensland, Perth, WA, Australia            
            Telethon Kids Institute, University of Western Australia, Perth, WA, Australia            
            Cited By :20            
            Export Date: 9 March 2022            
            CODEN: RSPIF            
            Correspondence Address: Gray, D.; Department of Paediatrics and Child Health, South Africa; email: diane.gray@uct.ac.za
UR  - https://doi.org/10.1111/resp.12579
EP  - 1114
IS  - 7
AV  - public
JF  - RESPIROLOGY
SN  - 1323-7799
ER  -