%0 Journal Article
%@ 1323-7799
%A  Gray Diane
%A  Willemse Lauren
%A  Visagie Ane
%A  Smith Emilee
%A  Czövek Dorottya
%A  Sly Peter D.
%A  Hantos Zoltán
%A  Hall Graham L.
%A  Zar Heather J.
%A Orvosi Fizikai és Orvosi Informatikai Intézet SZTE / SZAOK OFOII [2010-],
%D 2015
%F publicatio:35917
%J RESPIROLOGY
%N 7
%P 1108-1114
%T Lung function and exhaled nitric oxide in healthy unsedated African infants
%U http://publicatio.bibl.u-szeged.hu/35917/
%V 20
%X Background and objective: Population-appropriate lung function reference data are essential to accurately identify respiratory disease and measure response to interventions. There are currently no reference data in African infants. The aim was to describe normal lung function in healthy African infants. Methods: Lung function was performed on healthy South African infants enrolled in a birth cohort study, the Drakenstein child health study. Infants were excluded if they were born preterm or had a history of neonatal respiratory distress or prior respiratory tract infection. Measurements, made during natural sleep, included the forced oscillation technique, tidal breathing, exhaled nitric oxide and multiple breath washout measures. Results: Three hundred sixty-three infants were tested. Acceptable and repeatable measurements were obtained in 356 (98%) and 352 (97%) infants for tidal breathing analysis and exhaled nitric oxide outcomes, 345 (95%) infants for multiple breath washout and 293 of the 333 (88%) infants for the forced oscillation technique. Age, sex and weight-for-age z score were significantly associated with lung function measures. Conclusions: This study provides reference data for unsedated infant lung function in African infants and highlights the importance of using population-specific data.
%Z Department of Paediatrics and Child Health, University of Cape Town, Cape Town, 7700, South Africa                         MRC Unit, Child and Adolescent Lung Health, Cape Town, South Africa                         Division of Epidemiology and Biostatistics, School of Public Health and Family, University of Cape Town, Cape Town, South Africa                         Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary                         Queensland Children's Medical Research Institute, University of Queensland, Perth, WA, Australia                         Telethon Kids Institute, University of Western Australia, Perth, WA, Australia                         Cited By :20                         Export Date: 9 March 2022                         CODEN: RSPIF                         Correspondence Address: Gray, D.; Department of Paediatrics and Child Health, South Africa; email: diane.gray@uct.ac.za