TY  - JOUR
Y1  - 2023///
ID  - publicatio35902
EP  - 10
IS  - 2
A1  -  Chaya Shaakira
A1  -  MacGinty Rae
A1  -  Jacobs Carvern
A1  -  Githinji Leah
A1  -  Hlengwa Sipho
A1  -  Simpson Shannon J.
A1  -  Zar Heather J.
A1  -  Hantos Zoltán
A1  -  Gray Diane M.
TI  - Normal values of respiratory oscillometry in South African children and adolescents
AV  - public
N2  - Introduction Noninvasive measurement of respiratory impedance by oscillometry can be used in young children aged from 3 years and those unable to perform forced respiratory manoeuvres. It can discriminate between healthy children and those with respiratory disease. However, its clinical application is limited by the lack of reference data for African paediatric populations. The aim of the present study was to develop reference equations for oscillometry outcomes in South African children and adolescents. Methods Healthy subjects, enrolled in the Drakenstein Child Health Study, HIV-uninfected adolescents in the Cape Town Adolescent Antiretroviral Cohort and healthy children attending surgical outpatient clinics at Red Cross War Memorial Children's Hospital were measured with conventional spectral (6-32 Hz) and intra-breath (10 Hz) oscillometry. Stepwise linear regression was used to assess the relationship between respiratory variables and anthropometric predictors (height, sex, ancestry) to generate reference equations. Results A total of 692 subjects, 48.4% female, median age of 5.2 years (range: 3-17 years) were included. The median (interquartile range (IQR)) for weight for age z-score and height for age z-score was -0.42 (-1.11-0.35) and -0.65 (-1.43-0.35), respectively. Stepwise regression demonstrated that all the variables were significantly dependent on height only. Comparison to previous reference data indicated slightly higher resistance and lower compliance values in the smallest children. Conclusion We established the first respiratory oscillometry reference equations for African children and adolescents, which will facilitate use in early identification and management of respiratory disease. Our results suggest differences in oscillometry measures by ancestry but also highlight the lack of standardisation in methodology.
VL  - 9
JF  - ERJ OPEN RESEARCH
N1  - Department of Paediatrics and Child Health, Red Cross War Memorial Children?s Hospital and SA-MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa            
            Wal-yan Respiratory Centre, Telethon Kids Institute, Perth, Australia            
            School of Allied Health, Curtin University, Perth, Australia            
            Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary            
            Export Date: 17 July 2023            
            Correspondence Address: Gray, D.M.; Department of Paediatrics and Child Health, South Africa; email: diane.gray@uct.ac.za
SN  - 2312-0541
UR  - https://doi.org/10.1183/23120541.00371-2022
ER  -