relation: http://publicatio.bibl.u-szeged.hu/35772/
title: Neonatal Screening for Cystic Fibrosis in Hungary—First-Year Experiences
creator:  Xue Andrea
creator:  Lénárt István
creator:  Kincs Judit
creator:  Szabó Hajnalka
creator:  Párniczky Andrea
creator:  Balogh István
creator:  Deák Anna
creator:  Monostori Péter
creator:  Hegedűs Krisztina
creator:  Szabó Attila
creator:  Szatmári Ildikó
subject: 03.02. Klinikai orvostan
description: The aim of this study is to evaluate the strategy of the cystic fibrosis newborn screening (CFNBS) programme in Hungary based on the results of the first year of screening. A combined immunoreactive trypsinogen (IRT) and pancreatitis-associated protein (PAP) CFNBS protocol (IRT/IRT×PAP/IRT) was applied with an IRT-dependent safety net (SN). Out of 88,400 newborns, 256 were tested screen-positive. Fourteen cystic fibrosis (CF) and two cystic fibrosis-positive inconclusive diagnosis (CFSPID) cases were confirmed from the screen-positive cases, and two false-negative cases were diagnosed later. Based on the obtained results, a sensitivity of 88% and a positive predictive value (PPV) of 5.9% were calculated. Following the recognition of false-negative cases, the calculation method of the age-dependent cut-off was changed. In purely biochemical CFNBS protocols, a small protocol change, even after a short period, can have a significant positive impact on the performance. CFNBS should be monitored continuously in order to fine-tune the screening strategy and define the best local practices.
date: 2023
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/35772/1/NeonatalscreeningforcysticfibrosisinHungary-First-yearexperiences.pdf
identifier:     Xue Andrea;  Lénárt István;  Kincs Judit;  Szabó Hajnalka;  Párniczky Andrea;  Balogh István;  Deák Anna;  Monostori Péter;  Hegedűs Krisztina;  Szabó Attila;  Szatmári Ildikó: Neonatal Screening for Cystic Fibrosis in Hungary—First-Year Experiences.   INTERNATIONAL JOURNAL OF NEONATAL SCREENING, 9 (3).   ISSN 2409-515X (2023)     
identifier: doi:10.3390/ijns9030047
relation: https://doi.org/10.3390/ijns9030047
relation: 34139210
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.3390/ijns9030047
rights: info:eu-repo/semantics/openAccess