relation: http://publicatio.bibl.u-szeged.hu/35704/
title: Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats
creator:  Ayman Jázmin
creator:  Buzás András
creator:  Dochnal Roberta
creator:  Palotai Miklós
creator:  Jászberényi Miklós
creator:  Bagosi Zsolt
subject: 03.01. Általános orvostudomány
description: Background/Objectives: Ghrelin and growth hormone-releasing peptide 6 (GHRP-6) are peptides which can stimulate GH release, acting through the same receptor. Ghrelin and its receptor have been involved in reward sensation and addiction induced by natural and artificial drugs, including nicotine. The present study aimed to investigate the impacts of ghrelin and GHRP-6 on the horizontal and vertical activity in rats exposed to chronic nicotine treatment followed by acute nicotine withdrawal. Methods: Male and female Wistar rats were exposed daily to intraperitoneal (ip) injection with 2 mg/kg nicotine or saline solution for 7 days, twice a day (at 8:00 and at 20:00). In parallel, the rats were exposed daily to an intracerebroventricular (icv) injection with 1 μg/2 μL ghrelin or 1 μg/2 μL GHRP-6 or saline solution for 7 days, once a day (at 8:00). On the morning of the eighth day (12 h after the last ip administration) and the ninth day (24 h after the last ip administration), the horizontal and vertical activity were monitored in a conducta system. Results: On the eighth day, in nicotine-treated rats a significant hyperactivity was observed, that was reduced significantly by ghrelin and GHRP-6. On the ninth day, in nicotine-treated rats a significant hypoactivity was assessed that was reversed significantly by ghrelin and GHRP-6. Conclusions: Based on the present results, the changes in horizontal and vertical activity observed after 12 and 24 h of nicotine withdrawal can be attenuated by ghrelin and GHRP-6.
date: 2025
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/35704/1/biomedicines-13-00143.pdf
identifier:     Ayman Jázmin;  Buzás András;  Dochnal Roberta;  Palotai Miklós;  Jászberényi Miklós;  Bagosi Zsolt: Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats.   BIOMEDICINES, 13 (1).   ISSN 2227-9059 (2025)     
identifier: doi:10.3390/biomedicines13010143
relation: https://doi.org/10.3390/biomedicines13010143
relation: 35698320
language: eng