relation: http://publicatio.bibl.u-szeged.hu/34332/
title: The adjunctive effect of polydeoxyribonucleotide on bone formation in alveolar ridge preservation: A pre-clinical in vivo study
creator:  Ko Young-Chang
creator:  Lee Jungwon
creator:  Urbán István András
creator:  Seol Yang-Jo
creator:  Lee Yong-Moo
creator:  Koo Ki-Tae
subject: 03.02. Klinikai orvostan
description: AimThis study investigated the adjunctive effect of polydeoxyribonucleotide (PDRN) on bone formation in alveolar ridge preservation (ARP) sockets.Materials and MethodsBoth mandibular second, third and fourth premolars of eight beagle dogs were randomly divided into ARP and ARP/PDRN groups. Following tooth extraction, ARP procedures were conducted using collagenized alloplastic graft material and bilayer collagen membrane soaked with normal saline (ARP group) or PDRN (ARP/PDRN group) for 10 min before application. Both groups were also randomly allocated to 2-, 4- or 12-week healing subgroups. The primary endpoint of this study was to compare histomorphometric differences between ARP and ARP/PDRN. The secondary endpoints of this study were to compare micro-CT analysis and three-dimensional volumetric measurement between the two groups.ResultsIn the histomorphometric analysis, the ARP/PDRN group exhibited greater new bone formation at coronal, middle and total position compared with the ARP group at 2-week healing. The number of newly formed blood vessels was higher in the ARP/PDRN group than in the ARP group at 2- and 4-week healing. In micro-CT analysis, the mean new bone volume/total bone volume between ARP and ARP/PDRN was statistically significant at 2-week healing. Ridge volume alterations were significantly decreased in the ARP/PDRN group during entire healing time compared with the ARP group, especially on the buccal side.ConclusionsThe application of PDRN in ARP might provide additional benefits for early bone regeneration and maintenance of buccal ridge volume.
date: 2024
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/34332/1/34818825JClinicPeriodontology-2024-Ko-Theadjunctiveeffectofpolydeoxyribonucleotideonboneformationinalveolarridge.pdf
identifier:     Ko Young-Chang;  Lee Jungwon;  Urbán István András;  Seol Yang-Jo;  Lee Yong-Moo;  Koo Ki-Tae: The adjunctive effect of polydeoxyribonucleotide on bone formation in alveolar ridge preservation: A pre-clinical in vivo study.   JOURNAL OF CLINICAL PERIODONTOLOGY, 51 (8).  pp. 1034-1043.  ISSN 0303-6979 (2024)     
identifier: doi:10.1111/jcpe.13988
relation: https://doi.org/10.1111/jcpe.13988
relation: 34818825
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1111/jcpe.13988
rights: info:eu-repo/semantics/openAccess