relation: http://publicatio.bibl.u-szeged.hu/33887/
title: Reducing cardiovascular risk in immune‐mediated inflammatory diseases: Tumour necrosis factor inhibitors compared to conventional therapies—A systematic review and meta‐analysis
creator:  Galajda Noémi Ágnes
creator:  Meznerics Fanni Adél
creator:  Mátrai Péter
creator:  Fehérvári Péter
creator:  Lengyel Anna Sára
creator:  Kolonics Mária Veronika
creator:  Sipos Z.
creator:  Kemény Lajos Vince
creator:  Csupor Dezső
creator:  Hegyi Péter
creator:  Bánvölgyi András
creator:  Holló Péter
subject: 03.01. Általános orvostudomány
subject: 03.02. Klinikai orvostan
description: Immune‐mediated inflammatory disease (IMID) patients including psoriasis, inflammatory arthritides and bowel diseases have a higher risk of developing cardiovascular (CV) diseases compared to the general population. The increased CV risk may be promoted by tumour necrosis factor (TNF)‐α‐mediated immunological processes, which are present both in the pathomechanism of IMIDs and atherosclerosis. Our objective was to comprehensively investigate the effect of TNF inhibitors (TNFi) on CV risk compared with conventional therapies in IMIDs. The systematic literature search was conducted in three databases (MEDLINE, EMBASE, Cochrane Library) on 14 November 2022. Randomized controlled trials, cohort and case–control studies were eligible for inclusion. Outcomes consisted of the incidence of CV events, with major adverse cardiovascular events (MACE) as a main endpoint. A random‐effects meta‐analysis was performed by pooling fully adjusted multivariate hazard ratios (HR) and incidence rate ratios (IRR) with a 95% confidence interval (CI) comparing TNFis with conventional systemic non‐biologicals (CSNBs). Of a total of 8724 search results, 56 studies were included overall, of which 29 articles were eligible for the meta‐analysis, and 27 were involved in the systematic review. Including all IMIDs, the TNFi group showed a significantly reduced risk of MACE compared with the CSNB group (HR = 0.74, 95% confidence interval (CI) 0.58–0.95, p  = 0.025; IRR = 0.77, 95% CI 0.67–0.88, p  < 0.001). Subgroup analysis of Pso, PsA patients by pooling IRRs also confirmed the significantly decreased risk of MACE in TNFi‐treated patients compared with CSNB groups (IRR = 0.79, 95% CI 0.64–0.98). The observational nature of most included studies leading to high heterogeneity represents a limitation. Based on the results, TNFis may reduce the risk of CV events compared to CSNBs. Therefore, earlier use of TNFis compared to conventional systemic agents in the therapeutic sequence may benefit CV risk in IMID patients.
date: 2024
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/33887/1/AcadDermatolVenereol-2024-Galajda-ReducingcardiovascularriskinimmunemediatedinflammatorydiseasesTumour.pdf
identifier:     Galajda Noémi Ágnes;  Meznerics Fanni Adél;  Mátrai Péter;  Fehérvári Péter;  Lengyel Anna Sára;  Kolonics Mária Veronika;  Sipos Z.;  Kemény Lajos Vince;  Csupor Dezső;  Hegyi Péter;  Bánvölgyi András;  Holló Péter: Reducing cardiovascular risk in immune‐mediated inflammatory diseases: Tumour necrosis factor inhibitors compared to conventional therapies—A systematic review and meta‐analysis.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 38 (6).  pp. 1070-1088.  ISSN 0926-9959 (2024)     
identifier: doi:10.1111/jdv.19900
relation: https://doi.org/10.1111/jdv.19900
relation: 34723194
language: eng