TY  - JOUR
IS  - Suppl. 1
AV  - restricted
VL  - 26
Y1  - 1995///
JF  - JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
EP  - S31
ID  - publicatio32583
SP  - S20
TI  - Hemodynamic effects of calcium-sensitizing agents
N1  - Megjegyzés-20426975
SU: Suppl. 1
Megjegyzés-20426978
SU: Suppl. 1
Megjegyzés-20548704
SU: Suppl. 1
N2  - Over the last few years the development of calcium-sensitizing agents has led to a new approach to the treatment of congestive heart failure (CHF). These novel inotropic agents act directly on the contractile protein systems and correct the reduced responsiveness of the myofilaments to calcium. The resultant favorable inotropic activity of this new class of cardiotonic agents may represent an important pharmacologic approach to the future treatment of acute and chronic CHF. This brief review summarizes the cardiotonic effects of calcium sensitizers, with particular emphasis on the hemodynamic actions of these drugs in various in vitro and in vivo heart preparations. We also attempt to draw conclusions for the therapeutic exploitation of these agents and delineate their possible role in the therapy of CHF.
A1  -  Végh Ágnes
A1  -  Papp Gyula
A1  -  Udvary Éva
A1  -  Kaszala Károly
SN  - 0160-2446
UR  - http://doi.org/10.1097/00005344-199506261-00004
ER  -