%0 Journal Article
%@ 1023-3830
%A  Valen G.
%A  Runsiö M.
%A  Öwall A.
%A  Kaszaki József
%A  Nagy Sándor
%A  Rosenqvist M.
%A  Bergfieldt L.
%A  Vaage J.
%A Sebészeti Műtéttani Intézet SZTE / SZAOK SMI [2000-],
%D 1995
%F publicatio:32490
%J INFLAMMATION RESEARCH
%N 11
%P 499-503
%T CARDIAC RELEASE OF HISTAMINE AFTER VENTRICULAR-FIBRILLATION AND DEFIBRILLATION DURING INSERTION OF IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS (ICD)
%U http://publicatio.bibl.u-szeged.hu/32490/
%V 44
%X Histamine has inotropic, chronotropic, arrhythmogenic, and vasoactive effects, and is released from the heart in ischaemia-reperfusion injury. The effect of ventricular fibrillation (VF) and defibrillation (DEF) on histamine release was investigated in 9 anaesthetized patients undergoing transvenous implantation of ICD. Concomitant arterial and coronary sinus (CS) blood samples were drawn before induction of VF (duration 20 seconds), immediately after, and 2 and 5 min after DEF (18-24 Joules). Basal 2.5 +/- 6 nmol/l, and did not histamine level in CS was 1.1 +/- 0.2 nmol/l before VF (p < 0.008 compared to arterial), and increased to 2.5 +/- 0.6 nmol/l immediately after (p < 0.045 compared to basal), to 3 +/- 1.1 nmol/l 2 mill after (p < 0.45), and to 2.4 +/- 0.8 nmol/l 5 mill after VF. In the basal state there was an uptake of histamine across the coronary circulation. After VF/DEF the level of histamine increased in corollary venous blood, suggesting cardiac release of histamine.