relation: http://publicatio.bibl.u-szeged.hu/32490/ title: CARDIAC RELEASE OF HISTAMINE AFTER VENTRICULAR-FIBRILLATION AND DEFIBRILLATION DURING INSERTION OF IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS (ICD) creator: Valen G. creator: Runsiö M. creator: Öwall A. creator: Kaszaki József creator: Nagy Sándor creator: Rosenqvist M. creator: Bergfieldt L. creator: Vaage J. subject: 01.06. Biológiai tudományok subject: 03.01. Általános orvostudomány description: Histamine has inotropic, chronotropic, arrhythmogenic, and vasoactive effects, and is released from the heart in ischaemia-reperfusion injury. The effect of ventricular fibrillation (VF) and defibrillation (DEF) on histamine release was investigated in 9 anaesthetized patients undergoing transvenous implantation of ICD. Concomitant arterial and coronary sinus (CS) blood samples were drawn before induction of VF (duration 20 seconds), immediately after, and 2 and 5 min after DEF (18-24 Joules). Basal 2.5 +/- 6 nmol/l, and did not histamine level in CS was 1.1 +/- 0.2 nmol/l before VF (p < 0.008 compared to arterial), and increased to 2.5 +/- 0.6 nmol/l immediately after (p < 0.045 compared to basal), to 3 +/- 1.1 nmol/l 2 mill after (p < 0.45), and to 2.4 +/- 0.8 nmol/l 5 mill after VF. In the basal state there was an uptake of histamine across the coronary circulation. After VF/DEF the level of histamine increased in corollary venous blood, suggesting cardiac release of histamine. date: 1995 type: Folyóiratcikk type: PeerReviewed format: text identifier: http://publicatio.bibl.u-szeged.hu/32490/1/aok_klny_215_95.pdf identifier: Valen G.; Runsiö M.; Öwall A.; Kaszaki József; Nagy Sándor; Rosenqvist M.; Bergfieldt L.; Vaage J.: CARDIAC RELEASE OF HISTAMINE AFTER VENTRICULAR-FIBRILLATION AND DEFIBRILLATION DURING INSERTION OF IMPLANTABLE CARDIOVERTER-DEFIBRILLATORS (ICD). INFLAMMATION RESEARCH, 44 (11). pp. 499-503. ISSN 1023-3830 (1995) identifier: doi:10.1007/BF01837917 relation: https://doi.org/10.1007/BF01837917 relation: 1433483 language: eng relation: info:eu-repo/semantics/altIdentifier/doi/10.1007/BF01837917 rights: info:eu-repo/semantics/restrictedAccess