relation: http://publicatio.bibl.u-szeged.hu/32182/
title: Release of histamine from isolated rat hearts during reperfusion is not dependent on length of ischemic insult, or contents of histamine in cardiac tissue
creator:  Valen Guro
creator:  Kaszaki József
creator:  Szabo Ivan
creator:  Nagy Sándor
creator:  Vaage J
subject: 03.02. Klinikai orvostan
description: Release of histamine (H) by ischemia-reperfusion injury was investigated in isolated rat hearts (Langendorff model). The effect of 10, 15, 20, 25, 30, 40 and 60 min ischemia (n = 10 each) on H in the coronary effluent and in cardiac tissue was studied after 4 min reperfusion. Release of creatine kinase and lactate dehydrogenase in the coronary effluent increased with time of ischemia. Tissue H increased from 95 +/- 10 ng/g rat heart (mean +/- SEM) before ischemia to max 148 +/- 10 ng/g after 20 min ischemia (p < 0.002), and increased also after 15 (p < 0.0 1), 25 (p < 0.0 1), and 30 min (p < 0.045). H in the coronary effluent increased after 15 (from 16 +/- 3 to 26 +/- 2 pmol/min, p < 0.044), 30 (26 +/- 6 pmol/min, p < 0.027), and 60 min ischemia (47 + 6 pmol/min, p < 0.0044). Release of H during ischemia-reperfusion is neither dependent on the severity of the ischemic insult, nor on the level of tissue H.
date: 1993
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/32182/1/aok_klny_812_93.pdf
identifier:     Valen Guro;  Kaszaki József;  Szabo Ivan;  Nagy Sándor;  Vaage J: Release of histamine from isolated rat hearts during reperfusion is not dependent on length of ischemic insult, or contents of histamine in cardiac tissue.   AGENTS AND ACTIONS, 40 (1-2).  pp. 37-43.  ISSN 0065-4299 (1993)     
identifier: doi:10.1007/BF01976749
relation: https://doi.org/10.1007/BF01976749
relation: 1433420
language: eng