relation: http://publicatio.bibl.u-szeged.hu/32049/
title: Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion
creator:  Leprán István
creator:  Papp Gyula
subject: 03.01. Általános orvostudomány
subject: 03.02. Klinikai orvostan
description: The aim of the present study was to investigate the influence of moxonidine, a representative of I-1-imidazoline-receptor agonists, on arrhythmias induced by myocardial ischemia or reperfusion. Acute myocardial infarction was produced by tightening a previously placed loose silk loop around the coronary artery in conscious rats. Moxonidine (0.01, 0.03, or 0.10 mg/kg i.v., 10 min before coronary ligation) significantly decreased the incidence of ventricular tachycardia during the first 15 min of infarction (70 versus 100% in controls), and the number of animals that survived without developing any arrhythmia was increased (15, 20, and 25%, respectively, versus 0%). Reperfusion-induced arrhythmias were produced by releasing a snare after 6 min of myocardial ischemia in anes-thetized, artificially ventilated rats. Reperfusion rapidly induced severe dysrhythmias in all of the control animals. Moxonidine pretreatment (0.03 and 0.10 mg/kg) decreased the incidence of ventricular fibrillation (25 and 30% versus 64%) and increased the number of animals that survived without developing any arrhythmia (20 and 25% versus O%), We conclude that moxonidine offers sig nificant protection against the development of arrhythmias induced by acute regional myocardial ischemia in conscious rats. Moxonidine pretreatment also provides a beneficial effect during reperfusion-induced arrhythmias that appear after a brief period of myocardial ischemia.
date: 1994
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/32049/1/aok_klny_654_94.pdf
identifier:     Leprán István;  Papp Gyula: Effect of moxonidine on arrhythmias induced by coronary artery occlusion and reperfusion.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 24.  S9-S15.  ISSN 0160-2446 (1994)     
identifier: doi:10.1097/00005344-199424001-00003
relation: https://doi.org/10.1097/00005344-199424001-00003
relation: 1131774
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1097/00005344-199424001-00003
rights: info:eu-repo/semantics/restrictedAccess