relation: http://publicatio.bibl.u-szeged.hu/32039/
title: The lymphocyte transformation test with sulphadiminidum and with prealbumin-sulphadiminidum complex in patients with drug allergy
creator:  Husz Sándor
creator:  Kenderessy Szabó Anna
creator:  Kiss Mária
creator:  Penke Botond
creator:  Dobozy Attila
subject: 03.02. Klinikai orvostan
description: Earlier results (the absence or a decreased level of prealbumin [PA] in the serum, a higher proportion of PA-bearing lymphocytes as antigen-binding cells, and the presence of PA in the eluate of lymphocytes in patients with drug allergy) permitted the conclusion that, besides its other relevant functions, PA may also behave as a hapten carrier protein. The lymphocyte transformation test (LTT) involving measurement of 3H-thymidine uptake was therefore carried out with sulphadiminidum (SA) alone, with the PA-SA complex, and with the albumin-SA complex in patients with proven (3 cases) or suspected (63 cases) sensitivity to SA. In all 3 cases with proven drug allergy to SA and in 5 of the 63 suspect cases, the LTT was positive in response to both the drug alone and to the PA-SA complex (The albumin-SA complex gave positivity in only one case). In 5 of the 63 suspect cases, the LTT was positive only in response to the PA-SA complex. It is suggested that the sensitivity of the LTT could be increased if the test could be run with a complex of a protein (hapten carrier?) and a drug.
date: 1994
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/32039/1/aok_klny_486_94.pdf
identifier:     Husz Sándor;  Kenderessy Szabó Anna;  Kiss Mária;  Penke Botond;  Dobozy Attila: The lymphocyte transformation test with sulphadiminidum and with prealbumin-sulphadiminidum complex in patients with drug allergy.   JOURNAL OF DERMATOLOGY, 21 (2).  pp. 84-86.  ISSN 0385-2407 (1994)     
identifier: doi:10.1111/j.1346-8138.1994.tb01419.x
relation: https://doi.org/10.1111/j.1346-8138.1994.tb01419.x
relation: 1050022
language: eng