TY  - JOUR
ID  - publicatio31967
AV  - restricted
A1  -  Kóbor Jen?
A1  -  Lázár János
A1  -  Fülöp Ferenc
A1  -  Bernáth Gábor
Y1  - 1994///
EP  - 828
VL  - 31
SN  - 0022-152X
JF  - JOURNAL OF HETEROCYCLIC CHEMISTRY
IS  - 4
TI  - Saturated heterocycles. Part 209. Synthesis of 1?cyclohexyl?substituted isoquinoline derivatives
N2  - In contrast with earlier literature data [7], both acrylic esters and acrylonitrile underwent Michael addition to 1-methyl-3,4-dihydroisoquinolines 14 to yield the diesters 5-9 or the dinitrile 10, respectively. Compounds S-10 were converted by Claisen condensation to 1-[(3'-methoxycarbonyl- or 1-[(3'-ethoxycarbonyl-4'-oxo)-1-cyclohexyl]-3,4-dihydroisoquinoline derivatives 11-16. Several derivatives of 12 were prepared. The new compounds possess various pharmacological actions.
UR  - https://doi.org/10.1002/jhet.5570310423
SP  - 825
ER  -