%0 Journal Article
%@ 0022-152X
%A  Kóbor Jenő
%A  Lázár János
%A  Fülöp Ferenc
%A  Bernáth Gábor
%A Gyógyszerkémiai Intézet SZTE / GYTK GYKI [2000-],
%D 1994
%F publicatio:31967
%J JOURNAL OF HETEROCYCLIC CHEMISTRY
%N 4
%P 825-828
%T Saturated heterocycles. Part 209. Synthesis of 1‐cyclohexyl‐substituted isoquinoline derivatives
%U http://publicatio.bibl.u-szeged.hu/31967/
%V 31
%X In contrast with earlier literature data [7], both acrylic esters and acrylonitrile underwent Michael addition to 1-methyl-3,4-dihydroisoquinolines 14 to yield the diesters 5-9 or the dinitrile 10, respectively. Compounds S-10 were converted by Claisen condensation to 1-[(3'-methoxycarbonyl- or 1-[(3'-ethoxycarbonyl-4'-oxo)-1-cyclohexyl]-3,4-dihydroisoquinoline derivatives 11-16. Several derivatives of 12 were prepared. The new compounds possess various pharmacological actions.