TY  - JOUR
A1  -  Zahran Magdy A.
A1  -  Kovács Lajos
A1  -  ElSakka Ibrahim
A1  -  Pedersen Erik B.
A1  -  Nielsen Claus
SN  - 0365-6233; 1521-4148
N1  - Nincs jelölve levelez? szerz?ség a közleményen. (TP, SZTE admin5)
UR  - https://doi.org/10.1002/ardp.19963290809
N2  - Aspirin (O-acetylsalicylic acid) has been used to synthesize prodrugs of 3'-azido-3'-deoxythymidine (AZT) and 3'-deoxy-3'-fluorothymidine (FLT). The mixed anhydride between aspirin and trifluoroacetic acid was synthesized and reacted with AZT and FLT to give the blocked nucleosides attached through the 5'-O position to the 2-position of 2-methyl-4H-1,3-benzodioxin-4-one. The prodrugs showed the same activities against HIV-1 in MT-4 cells as the original drugs. Hydrolysis of the synthesized prodrugs in the growth medium, used for anti-HIV investigations, resulted in formation of 5-O acetylated drugs which were subsequently hydrolyzed into the original drugs.
AV  - restricted
EP  - 420
TI  - The potential of aspirin in prodrug synthesis: A new potential delivery system of AZT and FLT
Y1  - 1996///
VL  - 329
JF  - ARCHIV DER PHARMAZIE
ID  - publicatio31831
SP  - 417
IS  - 8-9
ER  -