relation: http://publicatio.bibl.u-szeged.hu/31831/
title: The potential of aspirin in prodrug synthesis: A new potential delivery system of AZT and FLT
creator:  Zahran Magdy A.
creator:  Kovács Lajos
creator:  ElSakka Ibrahim
creator:  Pedersen Erik B.
creator:  Nielsen Claus
subject: 01.04. Kémiai tudományok
subject: 03.01. Általános orvostudomány
description: Aspirin (O-acetylsalicylic acid) has been used to synthesize prodrugs of 3'-azido-3'-deoxythymidine (AZT) and 3'-deoxy-3'-fluorothymidine (FLT). The mixed anhydride between aspirin and trifluoroacetic acid was synthesized and reacted with AZT and FLT to give the blocked nucleosides attached through the 5'-O position to the 2-position of 2-methyl-4H-1,3-benzodioxin-4-one. The prodrugs showed the same activities against HIV-1 in MT-4 cells as the original drugs. Hydrolysis of the synthesized prodrugs in the growth medium, used for anti-HIV investigations, resulted in formation of 5-O acetylated drugs which were subsequently hydrolyzed into the original drugs.
date: 1996
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/31831/1/aok_klny_261_96.pdf
identifier:     Zahran Magdy A.;  Kovács Lajos;  ElSakka Ibrahim;  Pedersen Erik B.;  Nielsen Claus: The potential of aspirin in prodrug synthesis: A new potential delivery system of AZT and FLT.   ARCHIV DER PHARMAZIE, 329 (8-9).  pp. 417-420.  ISSN 0365-6233; 1521-4148 (1996)     
identifier: doi:10.1002/ardp.19963290809
relation: https://doi.org/10.1002/ardp.19963290809
relation: 1505911
language: eng