TY  - JOUR
JF  - HETEROCYCLES
SP  - 625
AV  - restricted
EP  - 634
Y1  - 1996///
VL  - 42
IS  - 2
TI  - tert-Butylcyclopentane Derivatives. Part 8. Synthesis of tert-Butylcyclopentane-fused Pyrimidin-4-ones
N1  - Saját lista sorszáma: 344 (S.P.)
SN  - 0385-5414; 1881-0942
UR  - https://doi.org/10.3987/com-95-s54
ID  - publicatio31816
N2  - In the reactions of ethyl (1 R*,2S*,4S*)-2-amino-4-tert-butyl-1-cyclopentanecarboxylate (4) or (1R*,3S*,5S*)-3-tert-butyl-6-azabicyclo[3.2.0]heptan-7-one (2) or (1R*,2S*,4S*)-2-amino-4-tert-butyl-1-cyclopentanecarboxamide (6) with imidates or triethyl orthobenzoate, tert-butylcyclopentane-fused dihydropy-rimidin-4-ones (7a-e) were prepared. The azetidinone (2) with lactim ethers furnished pyrrolo-, pyrido- and azepino[1,2-a]pyrimidin-4-ones (8-10) in ring-enlargement reactions. Ethyl (1R*,2S*,4S*)-2-amino-4-tert-butyl-1-cyclopentanecarboxylate (4) and ethyl (1R*,2S*,4S*)-2-benzylamino-4-tert-butyl-1 cyclopentanecarboxylate (5) and potassium cyanate or phenyl isocyanate or potassium thiocyanate or phenyl isothiocyanate, yielded pyrimidine-2,4-diones or 2-thioxopyrimidin-4-ones (11-22).
A1  -  Szakonyi Zsolt
A1  -  Fülöp Ferenc
A1  -  Bernáth Gábor
A1  -  Sohár Pál
ER  -