relation: http://publicatio.bibl.u-szeged.hu/31816/
title: tert-Butylcyclopentane Derivatives. Part 8. Synthesis of tert-Butylcyclopentane-fused Pyrimidin-4-ones
creator:  Szakonyi Zsolt
creator:  Fülöp Ferenc
creator:  Bernáth Gábor
creator:  Sohár Pál
subject: 03.01. Általános orvostudomány
description: In the reactions of ethyl (1 R*,2S*,4S*)-2-amino-4-tert-butyl-1-cyclopentanecarboxylate (4) or (1R*,3S*,5S*)-3-tert-butyl-6-azabicyclo[3.2.0]heptan-7-one (2) or (1R*,2S*,4S*)-2-amino-4-tert-butyl-1-cyclopentanecarboxamide (6) with imidates or triethyl orthobenzoate, tert-butylcyclopentane-fused dihydropy-rimidin-4-ones (7a-e) were prepared. The azetidinone (2) with lactim ethers furnished pyrrolo-, pyrido- and azepino[1,2-a]pyrimidin-4-ones (8-10) in ring-enlargement reactions. Ethyl (1R*,2S*,4S*)-2-amino-4-tert-butyl-1-cyclopentanecarboxylate (4) and ethyl (1R*,2S*,4S*)-2-benzylamino-4-tert-butyl-1 cyclopentanecarboxylate (5) and potassium cyanate or phenyl isocyanate or potassium thiocyanate or phenyl isothiocyanate, yielded pyrimidine-2,4-diones or 2-thioxopyrimidin-4-ones (11-22).
date: 1996
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/31816/1/aok_klny_213_96.pdf
identifier:     Szakonyi Zsolt;  Fülöp Ferenc;  Bernáth Gábor;  Sohár Pál: tert-Butylcyclopentane Derivatives. Part 8. Synthesis of tert-Butylcyclopentane-fused Pyrimidin-4-ones.   HETEROCYCLES, 42 (2).  pp. 625-634.  ISSN 0385-5414; 1881-0942 (1996)     
identifier: doi:10.3987/com-95-s54
relation: https://doi.org/10.3987/com-95-s54
relation: 27991
language: eng