TY  - JOUR
UR  - http://publicatio.bibl.u-szeged.hu/31737/
EP  - 23
SN  - 0001-6659
VL  - 67
SP  - 19
Y1  - 1997///
N2  - Rectal suppositories containing Furosemide (4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid) and Furosemide Sodium were formulated with various suppository bases. The in vitro drug release of Massa Estarinum 299 proved to be the best from among the vehicles having various physical-chemical properties. The diuretic effect of the two suppositories was compared in a prospective, cross-over clinical trial including 8 patients. Both preparations have induced and increase of urine flow, which was comparable to the diuretic effect of the tablet. Thus the possibility of rectal use has been added to the modalities of therapeutic Furosemide administration.
ID  - publicatio31737
JF  - ACTA PHARMACEUTICA HUNGARICA
TI  - Furosemid-tartalmú kúpok el?állítása, in vitro vizsgálata és a preklinikai alkalmazás tapasztalatai
IS  - 1
A1  -  Regdon Géza
A1  -  Fazekas Tamás
A1  -  Regdon Géza (ifj.)
A1  -  Selmeczi Béla
AV  - restricted
ER  -