TY  - JOUR
Y1  - 2006///
EP  - 397
IS  - 4
TI  - Obtaining and physical-chemical characterization of inclusion complex of a sulphonamidic diuretic with methylated beta-cyclodextrine [Objinerea §i caracterizarea fizico-chimicä a compu§ilor de incluziune ai unui diuretic sulfonamidic cu ß-ciclodextrinä metilatä]
SP  - 392
A1  -  Soica C.
A1  -  Gyéresi Árpád
A1  -  Aigner Zoltán
A1  -  Kata Mihály
A1  -  Dehelean C.
ID  - publicatio30630
JF  - REVISTA DE CHIMIE
VL  - 57
AV  - restricted
N2  - Furosemide is a practically insoluble in water sulphonamidic diuretic, used for the treatment of edema and hypertension. Randomly-methylated-beta-cyclodextrin(RAMEB) was used as a host molecule to improve its solubility in water, via inclusion complex formation. Different molar ratios (1: 1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used in order to obtain the inclusion complexes. Phase solubility diagram of furosemide and RAMEB was constructed and a diagram of A(L) type was obtained, with a stability constant of 130 M-1. The inclusion complexes were analysed by in vitro dissolution tests, differential scanning calorimetry and X-ray diffraction. As water solubility increased, the partition coefficients of the products decreased.
UR  - http://publicatio.bibl.u-szeged.hu/30630/
SN  - 0034-7752
ER  -