relation: http://publicatio.bibl.u-szeged.hu/30630/
title: Obtaining and physical-chemical characterization of inclusion complex of a sulphonamidic diuretic with methylated beta-cyclodextrine [Objinerea §i caracterizarea fizico-chimicä a compu§ilor de incluziune ai unui diuretic sulfonamidic cu ß-ciclodextrinä metilatä]
creator:  Soica C.
creator:  Gyéresi Árpád
creator:  Aigner Zoltán
creator:  Kata Mihály
creator:  Dehelean C.
subject: 01.04. Kémiai tudományok
subject: 03.01. Általános orvostudomány
description: Furosemide is a practically insoluble in water sulphonamidic diuretic, used for the treatment of edema and hypertension. Randomly-methylated-beta-cyclodextrin(RAMEB) was used as a host molecule to improve its solubility in water, via inclusion complex formation. Different molar ratios (1: 1, 1:2) and various preparation methods (physical mixing, kneading, ultrasonication) were used in order to obtain the inclusion complexes. Phase solubility diagram of furosemide and RAMEB was constructed and a diagram of A(L) type was obtained, with a stability constant of 130 M-1. The inclusion complexes were analysed by in vitro dissolution tests, differential scanning calorimetry and X-ray diffraction. As water solubility increased, the partition coefficients of the products decreased.
date: 2006
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/30630/1/aok_klny_318_06.pdf
identifier:     Soica C.;  Gyéresi Árpád;  Aigner Zoltán;  Kata Mihály;  Dehelean C.: Obtaining and physical-chemical characterization of inclusion complex of a sulphonamidic diuretic with methylated beta-cyclodextrine [Objinerea §i caracterizarea fizico-chimicä a compu§ilor de incluziune ai unui diuretic sulfonamidic cu ß-ciclodextrinä metilatä].   REVISTA DE CHIMIE, 57 (4).  pp. 392-397.  ISSN 0034-7752 (2006)     
relation: 1883473
language: rum