%A  Ambrus Rita
%A  Aigner ZoltĂĄn
%A  Berkesi OttĂł
%A  Soica C
%A  RĂŠvĂŠsz Piroska
%P 1051-1054
%X Poorly water-soluble drugs, such as nifluminic acid-important
anti-inflammatory drug-offer challenging problems in drug formulation
as poor solubility is generally associated to poor dissolution
characteristic and thus, to poor oral bioavailibility. In order to
increase the degree of dissolution and solubility of nifluminic acid,
products were prepared with polyvinylpyrrolidone K-25, using physical
mixing and solvent evaporation methods. The drug-polymer interactions
in the solid state were investigated by using hot-stage microscopy,
differential scanning calorimetry, Fourier transform infrared
spectroscopy and X-ray powder diffraction. The results suggested that
polyvinylpyrrolidone may inhibit the association of the drug molecule
to form the crystal nucleus and, thereby inhibit crystal growth. In the
physical mixtures, the nifluminic acid was dissolved in the melted
polyvinylpyrrolidone, whereas the solid dispersions contained
nifluminic acid in the amorphous state.
%D 2006
%N 10
%R MTMT:1168265
%I szte
%V 57
%J REVISTA DE CHIMIE
%L publicatio30622
%T Determination of the structural interaction of nifluminic acid-PVP solid dispersions