relation: http://publicatio.bibl.u-szeged.hu/30622/
title: Determination of the structural interaction of nifluminic acid-PVP solid dispersions
creator:  Ambrus Rita
creator:  Aigner Zoltán
creator:  Berkesi Ottó
creator:  Soica C
creator:  Révész Piroska
subject: 01.04. Kémiai tudományok
subject: 03.01. Általános orvostudomány
description: Poorly water-soluble drugs, such as nifluminic acid-important anti-inflammatory drug-offer challenging problems in drug formulation as poor solubility is generally associated to poor dissolution characteristic and thus, to poor oral bioavailibility. In order to increase the degree of dissolution and solubility of nifluminic acid, products were prepared with polyvinylpyrrolidone K-25, using physical mixing and solvent evaporation methods. The drug-polymer interactions in the solid state were investigated by using hot-stage microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy and X-ray powder diffraction. The results suggested that polyvinylpyrrolidone may inhibit the association of the drug molecule to form the crystal nucleus and, thereby inhibit crystal growth. In the physical mixtures, the nifluminic acid was dissolved in the melted polyvinylpyrrolidone, whereas the solid dispersions contained nifluminic acid in the amorphous state.
date: 2006
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/30622/1/aok_klny_6_06.pdf
identifier:     Ambrus Rita;  Aigner Zoltán;  Berkesi Ottó;  Soica C;  Révész Piroska: Determination of the structural interaction of nifluminic acid-PVP solid dispersions.   REVISTA DE CHIMIE, 57 (10).  pp. 1051-1054.  ISSN 0034-7752 (2006)     
relation: 1168265
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/
rights: info:eu-repo/semantics/restrictedAccess