relation: http://publicatio.bibl.u-szeged.hu/29407/
title: Elevation of hilar mossy cell activity suppresses hippocampal excitability and avoidance behavior
creator:  Wang Kai-Yi
creator:  Wu Jei-Wei
creator:  Cheng Jen-Kun
creator:  Chen Chun-Chung
creator:  Wong Wai-Yi
creator:  Averkin Róbert
creator:  Tamás Gábor
creator:  Nakazawa Kazu
creator:  Lien Cheng-Chang
subject: 01.06. Biológiai tudományok
subject: 03.01. Általános orvostudomány
description: Modulation of hippocampal dentate gyrus (DG) excitability regulates anxiety. In the DG, glutamatergic mossy cells (MCs) receive the excitatory drive from principal granule cells (GCs) and mediate the feedback excitation and inhibition of GCs. However, the circuit mechanism by which MCs regulate anxiety-related information routing through hippocampal circuits remains unclear. Moreover, the correlation between MC activity and anxiety states is unclear. In this study, we first demonstrate, by means of calcium fiber photometry, that MC activity in the ventral hippocampus (vHPC) of mice increases while they explore anxiogenic environments. Next, juxtacellular recordings reveal that optogenetic activation of MCs preferentially recruits GABAergic neurons, thereby suppressing GCs and ventral CA1 neurons. Finally, chemogenetic excitation of MCs in the vHPC reduces avoidance behaviors in both healthy and anxious mice. These results not only indicate an anxiolytic role of MCs but also suggest that MCs may be a potential therapeutic target for anxiety disorders.
date: 2021
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/29407/3/32250210.pdf
identifier:     Wang Kai-Yi;  Wu Jei-Wei;  Cheng Jen-Kun;  Chen Chun-Chung;  Wong Wai-Yi;  Averkin Róbert;  Tamás Gábor;  Nakazawa Kazu;  Lien Cheng-Chang: Elevation of hilar mossy cell activity suppresses hippocampal excitability and avoidance behavior.   CELL REPORTS, 36 (11).   ISSN 2211-1247 (2021)     
identifier: doi:10.1016/j.celrep.2021.109702
relation: https://doi.org/10.1016/j.celrep.2021.109702
relation: 32250210
language: eng