relation: http://publicatio.bibl.u-szeged.hu/28079/
title: Renal cell carcinoma in end-stage renal disease: A retrospective study in patients from Hungary
creator:  Semjén Dávid
creator:  Dénes Borbála
creator:  Somorácz Áron
creator:  Fintha Attila
creator:  Forika Gertrud
creator:  Jenei Alex
creator:  Dobi Deján
creator:  Micsik Tamás
creator:  Eizler Kornélia Veronika
creator:  Giba Nándor
creator:  Sánta Fanni Viktória
creator:  Sejben Anita
creator:  Iványi Béla
creator:  Kuthi Levente
subject: 03.02. Klinikai orvostan
description: Introduction: End-stage renal disease (ESRD) and acquired cystic kidney disease (ACKD) are known risk factors for renal cell carcinoma (RCC). Hereby, the clinicopathological features of RCCs developed in ESRD were investigated. Methods: A database consisting of 34 tumors from 31 patients with ESRD among 2 566 nephrectomy samples of RCC was built. The demographic, clinical, and follow-up data along with pathological parameters were analyzed. The RCCs were diagnosed according to the current WHO Classification of Urinary and Male Genital Tumors. Results: Twenty-two tumors developed in men and 12 in women, with a median age of 56 years (range: 27-75 years). The causes of ESRD were glomerulonephritis (n=7), hypertensive kidney disease (n=6), autosomal dominant polycystic kidney disease (n=6), chronic pyelonephritis (n=4), diabetic nephropathy (n=3), chemotherapy-induced nephropathy (n=1), and undetermined (n=4). ACKD complicated ESRD in 12 patients. The following histological subtypes were identified: clear cell RCC (n=19), papillary RCC (n=5), clear cell papillary tumor (n=5), ACKD RCC (n=3), and eosinophilic solid and cystic RCC (n=2). The median tumor size was 31 mm (range: 10-80 mm), and 32 tumors were confined to the kidney (pT1-pT2). There was no tumor-specific death during the period of this study. Progression was registered in one patient.Conclusion: In our cohort, the most common RCC subtype was clear cell RCC (55%), with a frequency that exceeded international data appreciably (14-25%). The incidence of clear cell papillary tumor and ACKD RCC (14.7% and 8.5%) was lower than data reported in the literature (30% and 40%). Our results indicate a favorable prognosis of RCC in ESRD.
date: 2023
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/28079/3/33602988_megjelent.pdf
format: text
identifier: http://publicatio.bibl.u-szeged.hu/28079/1/000529276.pdf
identifier:     Semjén Dávid;  Dénes Borbála;  Somorácz Áron;  Fintha Attila;  Forika Gertrud;  Jenei Alex;  Dobi Deján;  Micsik Tamás;  Eizler Kornélia Veronika;  Giba Nándor;  Sánta Fanni Viktória;  Sejben Anita;  Iványi Béla;  Kuthi Levente: Renal cell carcinoma in end-stage renal disease: A retrospective study in patients from Hungary.   PATHOBIOLOGY, 90 (5).  pp. 322-332.  ISSN 1015-2008 (2023)     
identifier: doi:10.1159/000529276
relation: https://doi.org/10.1159/000529276
relation: 33602988
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1159/000529276
rights: info:eu-repo/semantics/openAccess