relation: http://publicatio.bibl.u-szeged.hu/27953/
title: Application of hydroxyproline derivatives in enantioselective α-amination reactions in organic and aqueous environments: a structure-activity relationship study
creator:  Gurka András Attila
creator:  Szőri Kornél
creator:  Szőri Milán
creator:  Bartók Mihály
creator:  London Gábor
subject: 01.04. Kémiai tudományok
description: We examined the activity of a series of L-hydroxyproline derivatives in enantioselective alpha-amination reaction between diethyl azodicarboxylate and propanal both in organic and aqueous media. In organic media most of the catalysts showed high activity and enantioselectivities comparable to that accessible with L-proline that is among the best catalysts in the reaction. The catalysts showed good activity under aqueous conditions as well; however, only low enantioselectivities were obtained in this case, primarily due to the racemisation of the product under the reaction conditions. Thus, the attempted achiral acid/base additive-driven stereocontrol was not feasible on a practical level.
date: 2017
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/27953/1/s11224-016-0873-z.pdf
identifier:     Gurka András Attila;  Szőri Kornél;  Szőri Milán;  Bartók Mihály;  London Gábor: Application of hydroxyproline derivatives in enantioselective α-amination reactions in organic and aqueous environments: a structure-activity relationship study.   STRUCTURAL CHEMISTRY, 28 (2).  pp. 415-421.  ISSN 1040-0400 (2017)     
identifier: doi:10.1007/s11224-016-0873-z
relation: https://doi.org/10.1007/s11224-016-0873-z
relation: 30452962
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1007/s11224-016-0873-z
rights: info:eu-repo/semantics/restrictedAccess