relation: http://publicatio.bibl.u-szeged.hu/27789/
title: Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis
creator:  Ambrosini-Spaltro Andrea
creator:  Di Donato Francesco
creator:  Saragoni Luca
creator:  Cserni Gábor
creator:  Rakha Emad
creator:  Foschini Maria Pia
subject: 03.02. Klinikai orvostan
description: (1) Background: The prognostic factors of microinvasive (≤1 mm) breast carcinoma are not completely clear. The aim of this study was to perform a systematic review and meta-analysis to clarify these factors. (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology was followed. Two databases were interrogated, PubMed and Embase, and papers in English were included to address this question. The selected studies were those that reported on female patients affected by microinvasive carcinoma, and on prognostic factors with a hazard ratio (HR) for disease-free survival (DFS) and overall survival (OS). (3) Results: In total, 618 records were identified. After removing duplicates (166), identification, and screening (336 by title and abstract alone, 116 by full text and eventual supplementary material), 5 papers were selected. Seven different meta-analyses were conducted in this study, all referring to DFS, analyzing the following prognostic factors: estrogen receptor, progesterone receptor, HER2 status, multifocality and grade of microinvasion, patient’s age, and lymph node status. Only lymph node status was associated with prognosis and DFS (total number of cases: 1528; Z = 1.94; p = 0.05). The other factors examined did not significantly affect prognosis (p > 0.05). (4) Conclusions: Positive lymph node status significantly worsens prognosis in patients with microinvasive breast carcinoma.
date: 2023
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/27789/1/Cancers-2023-15-03007-AmbrosiniA-MicroinvasionPrognosisMetaanal.pdf
identifier:     Ambrosini-Spaltro Andrea;  Di Donato Francesco;  Saragoni Luca;  Cserni Gábor;  Rakha Emad;  Foschini Maria Pia: Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis.   CANCERS, 15 (11).   ISSN 2072-6694 (2023)     
identifier: doi:10.3390/cancers15113007
relation: https://doi.org/10.3390/cancers15113007
relation: 34043317
language: eng