relation: http://publicatio.bibl.u-szeged.hu/27600/ title: Alterations in the action potential of Aplysia neurons evoked by a phorbolester are mediated by protein kinase C creator: Papp András creator: Klee Manfred R. subject: 03.01. Általános orvostudomány description: Alterations in the parameters of action potentials upon changes in protein kinase C (PKC) activity were studied on neurons of the visceral ganglion of Aplysia californica. The amplitude and maximum speed of the up-and downstroke of the action potentials (APs) were measured. Intracellularly injected PKC and intra-and extracellularly applied phorbol-12,13-diacetate (PDAc) had similar effects on the Aplysia neurons, the most prominent being an increase of the upstroke speed of the AP in every neuron. The non-PKC-activating 4Îą-phorbol didecanoate had no effect, and the effects of the PKC blocker H-7 were opposite to those of PDAc. It was concluded that the changes of the AP evoked by PDAc are mediated through PKC activation. date: 1995 type: Folyóiratcikk type: PeerReviewed format: text identifier: http://publicatio.bibl.u-szeged.hu/27600/1/PappA-Klee-Bres.pdf identifier: Papp András; Klee Manfred R.: Alterations in the action potential of Aplysia neurons evoked by a phorbolester are mediated by protein kinase C. BRAIN RESEARCH, 684 (1). pp. 107-111. ISSN 0006-8993 (1995) identifier: doi:10.1016/0006-8993(95)00437-U relation: https://doi.org/10.1016/0006-8993%2895%2900437-U relation: 1240485 language: eng