relation: http://publicatio.bibl.u-szeged.hu/27600/
title: Alterations in the action potential of Aplysia neurons evoked by a phorbolester are mediated by protein kinase C
creator:  Papp András
creator:  Klee Manfred R.
subject: 03.01. Általános orvostudomány
description: Alterations in the parameters of action potentials upon changes in protein kinase C (PKC) activity were studied on neurons of the visceral ganglion of Aplysia californica. The amplitude and maximum speed of the up-and downstroke of the action potentials (APs) were measured. Intracellularly injected PKC and intra-and extracellularly applied phorbol-12,13-diacetate (PDAc) had similar effects on the Aplysia neurons, the most prominent being an increase of the upstroke speed of the AP in every neuron. The non-PKC-activating 4Îą-phorbol didecanoate had no effect, and the effects of the PKC blocker H-7 were opposite to those of PDAc. It was concluded that the changes of the AP evoked by PDAc are mediated through PKC activation.
date: 1995
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/27600/1/PappA-Klee-Bres.pdf
identifier:     Papp András;  Klee Manfred R.: Alterations in the action potential of Aplysia neurons evoked by a phorbolester are mediated by protein kinase C.   BRAIN RESEARCH, 684 (1).  pp. 107-111.  ISSN 0006-8993 (1995)     
identifier: doi:10.1016/0006-8993(95)00437-U
relation: https://doi.org/10.1016/0006-8993%2895%2900437-U
relation: 1240485
language: eng