relation: http://publicatio.bibl.u-szeged.hu/26537/
title: Synthesis of a Pyrrolo[1,2-a]quinazoline-1,5-dione Derivative by Mechanochemical Double Cyclocondensation Cascade
creator:  Kolcsár Vanessza Judit
creator:  Szőllősi György
subject: 01.04. Kémiai tudományok
description: N-heterocyclic compounds, such as quinazolinone derivatives, have significant biological activities. Nowadays, as the demand for environmentally benign, sustainable processes increases, the application of compounds from renewable sources, easily separable heterogeneous catalysts and efficient, alternative activation methods is of great importance. In this study, we have developed a convenient, green procedure for the preparation of 3a-methyl-2,3,3a,4-tetrahydropyrrolo[1,2-a]quinazoline-1,5-dione through a double cyclocondensation cascade using anthranilamide and ethyl levulinate. Screening of various heterogeneous Brønsted acid catalysts showed that Amberlyst® 15 is a convenient choice. By applying mechanochemical activation in the preparation of this N-heterotricyclic compound for the first time, it was possible to shorten the necessary time to three hours compared to the 24 h needed under conventional conditions to obtain a high yield of the target product.
date: 2022
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/26537/1/Molecules_2022_5671_Kolcsar.pdf
identifier:     Kolcsár Vanessza Judit;  Szőllősi György: Synthesis of a Pyrrolo[1,2-a]quinazoline-1,5-dione Derivative by Mechanochemical Double Cyclocondensation Cascade.   MOLECULES, 27 (17).   ISSN 1420-3049 (2022)     
identifier: doi:10.3390/molecules27175671
relation: https://doi.org/10.3390/molecules27175671
relation: 33082606
language: eng