relation: http://publicatio.bibl.u-szeged.hu/24826/
title: Modeling the waning and boosting of immunity from infection or vaccination
creator:  Carlsson Rose-Marie
creator:  Childs Lauren M.
creator:  Feng Zhilan
creator:  Glasser John W.
creator:  Heffernan Jane M.
creator:  Li Jing
creator:  Röst Gergely
subject: 01.01. Matematika
description: Immunity following natural infection or immunization may wane, increasing susceptibility to infection with time since infection or vaccination. Symptoms, and concomitantly infectiousness, depend on residual immunity. We quantify these phenomena in a model population composed of individuals whose susceptibility, infectiousness, and symptoms all vary with immune status. We also model age, which affects contact, vaccination and possibly waning rates. The resurgences of pertussis that have been observed wherever effective vaccination programs have reduced typical disease among young children follow from these processes. As one example, we compare simulations with the experience of Sweden following resumption of pertussis vaccination after the hiatus from 1979 to 1996, reproducing the observations leading health authorities to introduce booster doses among school-aged children and adolescents in 2007 and 2014, respectively. Because pertussis comprises a spectrum of symptoms, only the most severe of which are medically attended, accurate models are needed to design optimal vaccination programs where surveillance is less effective. (C) 2020 The Authors. Published by Elsevier Ltd.
date: 2020
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/24826/1/1-s2.0-S002251932030120X-main.pdf
identifier:     Carlsson Rose-Marie;  Childs Lauren M.;  Feng Zhilan;  Glasser John W.;  Heffernan Jane M.;  Li Jing;  Röst Gergely: Modeling the waning and boosting of immunity from infection or vaccination.   JOURNAL OF THEORETICAL BIOLOGY, 497.  Terjedeleme: 19 p.-Azonosító: 110265.  ISSN 0022-5193 (2020)     
identifier: doi:10.1016/j.jtbi.2020.110265
relation: http://doi.org/10.1016/j.jtbi.2020.110265
relation: 31366269
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jtbi.2020.110265
rights: info:eu-repo/semantics/openAccess