%T Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions
%X Bismuth subnitrate is reported herein as a simple and efficient catalyst for the atom-economical synthesis of methyl ketones via Markovnikov-type alkyne hydration. Besides an effective batch process under reasonably mild conditions, a chemically intensified continuous flow protocol was also developed in a packed-bed system. The applicability of the methodologies was demonstrated through hydration of a diverse set of terminal acetylenes. By simply switching the reaction medium from methanol to methanol-d(4), valuable trideuteromethyl ketones were also prepared. Due to the ready availability and nontoxicity of the heterogeneous catalyst, which eliminated the need for any special additives and/or harmful reagents, the presented processes display significant advances in terms of practicality and sustainability.
%P Terjedelem: 12-AzonosĂ­tĂł: 2864
%N 10
%D 2021
%I szte
%A  SzĂŠcsĂŠnyi Zsanett
%A  FĂźlĂśp Ferenc
%A  Ötvös Sándor Balázs
%L publicatio23030
%J MOLECULES
%V 26
%R MTMT:32242848 10.3390/molecules26102864