TY  - JOUR
TI  - Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions
EP  - Azonosító: 2864
IS  - 10
AV  - public
JF  - MOLECULES
VL  - 26
N2  - Bismuth subnitrate is reported herein as a simple and efficient catalyst for the atom-economical synthesis of methyl ketones via Markovnikov-type alkyne hydration. Besides an effective batch process under reasonably mild conditions, a chemically intensified continuous flow protocol was also developed in a packed-bed system. The applicability of the methodologies was demonstrated through hydration of a diverse set of terminal acetylenes. By simply switching the reaction medium from methanol to methanol-d(4), valuable trideuteromethyl ketones were also prepared. Due to the ready availability and nontoxicity of the heterogeneous catalyst, which eliminated the need for any special additives and/or harmful reagents, the presented processes display significant advances in terms of practicality and sustainability.
Y1  - 2021///
UR  - http://doi.org/10.3390/molecules26102864
SN  - 1420-3049
A1  -  Szécsényi Zsanett
A1  -  Fülöp Ferenc
A1  -  Ötvös Sándor Balázs
SP  - Terjedelem: 12
ID  - publicatio23030
ER  -