relation: http://publicatio.bibl.u-szeged.hu/23030/
title: Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions
creator:  Szécsényi Zsanett
creator:  Fülöp Ferenc
creator:  Ötvös Sándor Balázs
subject: 01.04. Kémiai tudományok
description: Bismuth subnitrate is reported herein as a simple and efficient catalyst for the atom-economical synthesis of methyl ketones via Markovnikov-type alkyne hydration. Besides an effective batch process under reasonably mild conditions, a chemically intensified continuous flow protocol was also developed in a packed-bed system. The applicability of the methodologies was demonstrated through hydration of a diverse set of terminal acetylenes. By simply switching the reaction medium from methanol to methanol-d(4), valuable trideuteromethyl ketones were also prepared. Due to the ready availability and nontoxicity of the heterogeneous catalyst, which eliminated the need for any special additives and/or harmful reagents, the presented processes display significant advances in terms of practicality and sustainability.
date: 2021
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/23030/1/Molecules_Szecsenyi_2021_2864.pdf
identifier:     Szécsényi Zsanett;  Fülöp Ferenc;  Ötvös Sándor Balázs: Bismuth Subnitrate-Catalyzed Markovnikov-Type Alkyne Hydrations under Batch and Continuous Flow Conditions.   MOLECULES, 26 (10).  Terjedelem: 12-Azonosító: 2864.  ISSN 1420-3049 (2021)     
identifier: doi:10.3390/molecules26102864
relation: http://doi.org/10.3390/molecules26102864
relation: 32242848
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules26102864
rights: info:eu-repo/semantics/openAccess