%0 Journal Article
%@ 2045-2322
%A  Gentiluomo Manuel
%A  Corradi Chiara
%A  Vanella Giuseppe
%A  Johansen Astrid Z.
%A  Strobel Oliver
%A  Szentesi Andrea Ildikó
%A  Milanetto Anna Caterina
%A  Hegyi Péter
%A  Kupcinskas Juozas
%A  Tavano Francesca
%A  Neoptolemos John P.
%A  Bozzato Dania
%A  Hackert Thilo
%A  Pezzilli Raffaele
%A  Johansen Julia S.
%A Transzlációs Medicina Intézet PTE / ÁOK TMI [2016-],
%A I. sz. Belgyógyászati Klinika SZTE / ÁOK I.BelK [2009-],
%D 2021
%F publicatio:21973
%J SCIENTIFIC REPORTS
%N 1
%P Terjedelem: 8 p-Azonosító: 7570
%T Lack of association of CD44-rs353630 and CHI3L2-rs684559 with pancreatic ductal adenocarcinoma survival
%U http://publicatio.bibl.u-szeged.hu/21973/
%V 11
%X Although pancreatic ductal adenocarcinoma (PDAC) survival is poor, there are differences in patients' response to the treatments. Detection of predictive biomarkers explaining these differences is of the utmost importance. In a recent study two genetic markers (CD44-rs353630 and CHI3L2-rs684559) were reported to be associated with survival after PDAC resection. We attempted to replicate the associations in 1856 PDAC patients (685 resected with stage I/II) from the PANcreatic Disease ReseArch (PANDoRA) consortium. We also analysed the combined effect of the two genotypes in order to compare our results with what was previously reported. Additional stratified analyses considering TNM stage of the disease and whether the patients received surgery were also performed. We observed no statistically significant associations, except for the heterozygous carriers of CD44-rs353630, who were associated with worse OS (HR = 5.01; 95% CI 1.58-15.88; p = 0.006) among patients with stage I disease. This association is in the opposite direction of those reported previously, suggesting that data obtained in such small subgroups are hardly replicable and should be considered cautiously. The two polymorphisms combined did not show any statistically significant association. Our results suggest that the effect of CD44-rs353630 and CHI3L2-rs684559 cannot be generalized to all PDAC patients.
%Z Megosztott utolsó szerzőség Export Date: 19 April 2021 Department of Biology, University of Pisa, Via Derna 1, Pisa, 56126, Italy                         Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan, Italy                         Sant’Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy                         Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark                         Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany                         Institute for Translational Medicine, Medical School, University of Pécs, Pecs, Hungary                         First Department of Medicine, University of Szeged, Szeged, Hungary                         Department of Surgery, Gastroenterology, Oncology-Clinica Chirurgica, University of Padua, Padua, Italy                         Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania                         Division of Gastroenterology and Research Laboratory, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Foggia, Italy                         Department of Medicine-Medicina Di Laboratorio, University of Padua, Padua, Italy                         Gastroenterology Unit, San Carlo Hospital, Potenza, Italy                         Department of Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark                         National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom                         Department of Oncology, Faculty of Medicine and Dentristry, Palacky University Olomouc, Olomouc, Czech Republic                         Department of Surgery, Erasmus Medical Center, Erasmus University, Rotterdam, Netherlands                         Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland                         Department of Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark                         Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University San Raffaele Scientific Institute, Milan, Italy                         Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic                         ARC-Net Research Centre, University of Verona, Verona, Italy                         Department of the Molecular Biology of Cancer, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic                         Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece                         Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany                         Export Date: 13 May 2021                         Correspondence Address: Campa, D.; Department of Biology, Via Derna 1, Italy; email: daniele.campa@unipi.it Department of Biology, University of Pisa, Via Derna 1, Pisa, 56126, Italy                         Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Milan, Italy                         Sant’Andrea Hospital, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy                         Department of Oncology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark                         Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany                         Institute for Translational Medicine, Medical School, University of Pécs, Pecs, Hungary                         First Department of Medicine, University of Szeged, Szeged, Hungary                         Department of Surgery, Gastroenterology, Oncology-Clinica Chirurgica, University of Padua, Padua, Italy                         Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania                         Division of Gastroenterology and Research Laboratory, Fondazione IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Foggia, Italy                         Department of Medicine-Medicina Di Laboratorio, University of Padua, Padua, Italy                         Gastroenterology Unit, San Carlo Hospital, Potenza, Italy                         Department of Medicine, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark                         National Institute for Health Research Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, United Kingdom                         Department of Oncology, Faculty of Medicine and Dentristry, Palacky University Olomouc, Olomouc, Czech Republic                         Department of Surgery, Erasmus Medical Center, Erasmus University, Rotterdam, Netherlands                         Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland                         Department of Surgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark                         Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University San Raffaele Scientific Institute, Milan, Italy                         Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic                         ARC-Net Research Centre, University of Verona, Verona, Italy                         Department of the Molecular Biology of Cancer, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic                         Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece                         Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany                         Export Date: 14 May 2021                         Correspondence Address: Campa, D.; Department of Biology, Via Derna 1, Italy; email: daniele.campa@unipi.it Funding Agency and Grant Number: Univerity of Pisa; DKFZHelmholtz Association; Fondazione TizziFondazione CarifeFondazione Caritro; Fondazione Arpa; Ministry of Health of Czech RepublicMinistry of Health, Czech Republic [NV 19-03-00097]; Associazione Italiana Ricerca sul Cancro (AIRC 5 x 1000)Associazione Italiana per la Ricerca sul Cancro (AIRC) [12182]; Czech Ministry of HealthMinistry of Health, Czech Republic [NV19-08-00113]; Associazione Italiana Ricerca sul Cancro (AIRC)Associazione Italiana per la Ricerca sul Cancro (AIRC) [17177]; Italian Ministry of HealthMinistry of Health, Italy [RC1803GA32]; "5 x 1000" voluntary contribution             Funding text: This work was partially supported by: [D.C.; F.C.] intramural funds of Univerity of Pisa and DKFZ; [D.C.] Fondazione Tizzi (www.fondazionetizzi.it/); [D.C.] Fondazione Arpa (www.fondazionearpa.it); [B.M.D.] Ministry of Health of Czech Republic, NV 19-03-00097; [L.P.] Associazione Italiana Ricerca sul Cancro (AIRC 5 x 1000 n 12182); [P.S.] Czech Ministry of Health, project no. NV19-08-00113; [G. C.] Associazione Italiana Ricerca sul Cancro (AIRC IG IG 17177); [Division of Gastroenterology, Fondazione "Casa Sollievo della Sofferenza" IRCCS Hospital] Italian Ministry of Health (RC1803GA32) and the "5 x 1000" voluntary contribution.