%A  Vincze Anna
%A  Dargó Gergő
%A  Balogh GyĂśrgy Tibor
%X The present study was aimed to investigate the relationships between permeability and membrane retention values (logPe and MR) of the in vitro non-cellular permeability assay, corneal-PAMPA in comparison with experimental Caco-2 permeability data and calculated physicochemical properties (MW, clogP, clogD7.4 , TPSA). For the investigation, 50 structurally and physicochemically diverse drugs were selected and measured in PAMPA model optimized for corneal permeability. The results showed corneal-PAMPA model's orthogonality in terms of passive diffusion to the FDA approved Caco-2 as a gastrointestinal absorption model, while the comparison with physicochemical properties revealed trends between logPe , MR and the lipophilicity descriptors and TPSA.
%P 384-390
%N 3
%R MTMT:31323897 10.3311/PPch.15601
%J PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING
%I szte
%D 2020
%L publicatio19656
%V 64
%T Cornea-PAMPA as an Orthogonal in Vitro Physicochemical Model of Corneal Permeability