relation: http://publicatio.bibl.u-szeged.hu/19656/
title: Cornea-PAMPA as an Orthogonal in Vitro Physicochemical Model of Corneal Permeability
creator:  Vincze Anna
creator:  Dargó Gergő
creator:  Balogh György Tibor
description: The present study was aimed to investigate the relationships between permeability and membrane retention values (logPe and MR) of the in vitro non-cellular permeability assay, corneal-PAMPA in comparison with experimental Caco-2 permeability data and calculated physicochemical properties (MW, clogP, clogD7.4 , TPSA). For the investigation, 50 structurally and physicochemically diverse drugs were selected and measured in PAMPA model optimized for corneal permeability. The results showed corneal-PAMPA model's orthogonality in terms of passive diffusion to the FDA approved Caco-2 as a gastrointestinal absorption model, while the comparison with physicochemical properties revealed trends between logPe , MR and the lipophilicity descriptors and TPSA.
date: 2020
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/19656/1/15601-ArticleTextPDF-78108-1-10-20200525.pdf
identifier:     Vincze Anna;  Dargó Gergő;  Balogh György Tibor: Cornea-PAMPA as an Orthogonal in Vitro Physicochemical Model of Corneal Permeability.   PERIODICA POLYTECHNICA-CHEMICAL ENGINEERING, 64 (3).  pp. 384-390.  ISSN 0324-5853 (2020)     
identifier: doi:10.3311/PPch.15601
relation: http://doi.org/10.3311/PPch.15601
relation: 31323897
language: eng
relation: info:eu-repo/semantics/altIdentifier/doi/10.3311/PPch.15601
rights: info:eu-repo/semantics/openAccess