TY  - JOUR
UR  - http://publicatio.bibl.u-szeged.hu/19432/
N2  - A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks.
TI  - Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus
A1  -  Rauf Abdur
A1  -  Shaheen Usama Y.
A1  -  Raza Muslim
A1  -  Uddin Ghias
A1  -  Hadda, Ben Taibi
A1  -  Mabkhot Yahia Nasser
A1  -  Jehan Noor
A1  -  Ahmad Bashir
A1  -  Raza Saleem
A1  -  Molnár József
A1  -  Csonka Ákos
A1  -  Szabó Diána
ID  - publicatio19432
EP  - 825
AV  - restricted
N1  - Funding Agency and Grant Number: Higher Education Commission of PakistanHigher Education Commission of Pakistan [21:619/SRGP/RD/HEC/2014]; Deanship of Scientific at King Saud University [RG-1437-29]
            Funding text: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29).
Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan            
            Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia            
            Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt            
            State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, East Road of North Third RingChao Yang Dist., Beijing, China            
            Institute of Chemical Sciences, University of Peshawar, K.P.K Peshawar, Pakistan            
            LCM Laboratory, University of Mohamed 1st, Faculty of Sciences, Oujda, Morocco            
            Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia            
            Department of Geology, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan            
            Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, Pakistan            
            Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary            
            Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary            
            Export Date: 31 July 2020            
            Correspondence Address: Shaheen, U.; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura UniversitySaudi Arabia; email: usamayousef2003@yahoo.com            
            Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; chloroform, 67-66-3; Naphthoquinones; Plant Extracts            
            Funding details: Higher Education Commision, Pakistan, HEC, 21:619/SRGP/R&D/HEC/2014            
            Funding text 1: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29).
SN  - 1011-601X
SP  - 821
Y1  - 2018///
JF  - PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
IS  - 3
VL  - 31
ER  -