%0 Journal Article
%@ 1011-601X
%A  Rauf Abdur
%A  Shaheen Usama Y.
%A  Raza Muslim
%A  Uddin Ghias
%A  Hadda, Ben Taibi
%A  Mabkhot Yahia Nasser
%A  Jehan Noor
%A  Ahmad Bashir
%A  Raza Saleem
%A  Molnár József
%A  Csonka Ákos
%A  Szabó Diána
%A Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika SZTE / ÁOK FOG-FNYK [2000-],
%A Orvosi Mikrobiológiai és Immunbiológiai Intézet SZTE / ÁOK OMII [2002-],
%D 2018
%F publicatio:19432
%J PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
%N 3
%P 821-825
%T Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus
%U http://publicatio.bibl.u-szeged.hu/19432/
%V 31
%X A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks.
%Z Funding Agency and Grant Number: Higher Education Commission of PakistanHigher Education Commission of Pakistan [21:619/SRGP/RD/HEC/2014]; Deanship of Scientific at King Saud University [RG-1437-29]             Funding text: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29). Department of Chemistry, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan                         Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia                         Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt                         State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, East Road of North Third RingChao Yang Dist., Beijing, China                         Institute of Chemical Sciences, University of Peshawar, K.P.K Peshawar, Pakistan                         LCM Laboratory, University of Mohamed 1st, Faculty of Sciences, Oujda, Morocco                         Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia                         Department of Geology, University of Swabi, Anbar, Khyber Pakhtunkhwa, Pakistan                         Center of Biotechnology and Microbiology, University of Peshawar, Peshawar, KPK, Pakistan                         Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary                         Department of Oto-Rhino-Laryngology and Head-Neck Surgery, Faculty of Medicine, University of Szeged, Szeged, Hungary                         Export Date: 31 July 2020                         Correspondence Address: Shaheen, U.; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura UniversitySaudi Arabia; email: usamayousef2003@yahoo.com                         Chemicals/CAS: ABC transporter subfamily B, 149200-37-3, 208997-77-7; chloroform, 67-66-3; Naphthoquinones; Plant Extracts                         Funding details: Higher Education Commision, Pakistan, HEC, 21:619/SRGP/R&D/HEC/2014                         Funding text 1: The author (A.R) is grateful to Higher Education Commission of Pakistan for award of Research Start Up Grant No (21:619/SRGP/R&D/HEC/2014. The authors would also like to extend their sincere appreciation to Deanship of Scientific at King Saud University for its funding group No. (RG-1437-29).