relation: http://publicatio.bibl.u-szeged.hu/19432/
title: Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus
creator:  Rauf Abdur
creator:  Shaheen Usama Y.
creator:  Raza Muslim
creator:  Uddin Ghias
creator:  Hadda, Ben Taibi
creator:  Mabkhot Yahia Nasser
creator:  Jehan Noor
creator:  Ahmad Bashir
creator:  Raza Saleem
creator:  Molnár József
creator:  Csonka Ákos
creator:  Szabó Diána
description: A dimeric naphthoquinone namely dihydrodyspyrole R (1) was purified once more from Diospyros lotus. Dihydrodyspyrole R and chloroform fractions were evaluated for their effects on the reversion of multidrug resistance (MDR). The compounds (1) and extract exhibited promising MDR reversing effect in a dose-dependent manner against mouse T-lymphoma cell line. Molecular docking of compound 1 revealed the correlation between in-silico with in-vitro results. The molecular docking results showed that compound 1 is bind closely where co-crystal ligand of P-gp is present. But usually, computational investigation predicts that, if a compound gives lesser score then compound will exhibit good activity. Hence, the docking scores of compound 1 are the near to the Rhodamine. It is conclude that there are certain important structural features of compound 1which are responsible for the inhibiting potency of P-gp from mice. The computational Petra/Osiris/Molinspiration (POM) analysis confirms the possibility of use of compound 1 without side effect or less toxicity risks.
date: 2018
type: Folyóiratcikk
type: PeerReviewed
format: text
identifier: http://publicatio.bibl.u-szeged.hu/19432/1/3370144_MultidrugResistanceReversalActivityofextractandARareDimericNaphthoquinonefromDiospyroslotus.pdf
identifier:     Rauf Abdur;  Shaheen Usama Y.;  Raza Muslim;  Uddin Ghias;  Hadda, Ben Taibi;  Mabkhot Yahia Nasser;  Jehan Noor;  Ahmad Bashir;  Raza Saleem;  Molnár József;  Csonka Ákos;  Szabó Diána: Multidrug resistance reversal activity of extract and a rare dimeric naphthoquinone from Diospyros lotus.   PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 31 (3).  pp. 821-825.  ISSN 1011-601X (2018)     
relation: 3370144
language: eng