%0 Journal Article
%@ 0363-6135
%A  Fülöp Gábor Áron
%A  Tarantini Stefano
%A  Yabluchanskiy Andrij
%A  Molnár Andrea
%A  Prodan Calin
%A  Kiss Tamás
%A  Csipő Tamás
%A  Lipecz Ágnes
%A  Balasubramanian Priya
%A  Farkas Eszter
%A  Tóth Péter József
%A  Sorond Farzaneh
%A  Csiszar Anna
%A  Ungvári Zoltán István
%A Városmajori Szív- és Érgyógyászati Klinika SE / AOK / K [2012-],
%A Idegsebészeti Klinika PTE / ÁOK IK,
%A Neurotrauma kutatócsoport PTE / SZKK NTK [2014-],
%A Orvosi Fizikai és Orvosi Informatikai Intézet SZTE / ÁOK OFOII [2010-],
%A Klinikai Fiziológiai Tanszék DE / ÁOK / KardI KFiziolT [2014-],
%D 2019
%F publicatio:18569
%J AMERICAN JOURNAL OF PHYSIOLOGY: HEART AND CIRCULATORY PHYSIOLOGY
%N 5
%P H1124-H1140
%T Role of age-related alterations of the cerebral venous circulation in the pathogenesis of vascular cognitive impairment
%U http://publicatio.bibl.u-szeged.hu/18569/
%V 316
%X There has been an increasing appreciation of role of vascular contributions to cognitive impairment and dementia (VCID) associated with old age. Strong preclinical and translational evidence links age-related dysfunction and structural alterations of the cerebral arteries, arterioles and capillaries to the pathogenesis of many types of dementia in the elderly, including Alzheimer's disease. The low pressure, low velocity and large volume venous circulation of the brain also plays critical roles in the maintenance of homeostasis in the central nervous system. Despite its physiological importance, the role of age-related alterations of the brain venous circulation in the pathogenesis of vascular cognitive impairment and dementia is much less understood. This overview discusses the role of cerebral veins in the pathogenesis of VCID. Pathophysiological consequences of age-related dysregulation of the cerebral venous circulation are explored, including blood brain barrier disruption, neuroinflammation, exacerbation of neurodegeneration, development of cerebral microhemorrhages of venous origin, altered production of cerebrospinal fluid, impaired function of the glymphatics system, dysregulation of cerebral blood flow and ischemic neuronal dysfunction and damage. Understanding the age-related functional and phenotypic alterations of the cerebral venous circulation is critical for developing new preventive, diagnostic, and therapeutic approaches to preserve brain health in older individuals.
%Z Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review