TY  - JOUR
ID  - publicatio16703
A1  -  Peng Bai-Jing
A1  -  Hsueh Wen-Ting
A1  -  Fülöp Ferenc
A1  -  Yang Shyh-Chyun
AV  - restricted
SP  - 58
N1  - Funding Agency and Grant Number: National Science Council of the Republic of China [NSC101-2113-M-037-008-MY3]
            Funding text: This work was supported by a grant from the National Science Council of the Republic of China (NSC101-2113-M-037-008-MY3).
VL  - 43
SN  - 1144-0546
Y1  - 2019///
TI  - Platinum-catalyzed selective N-allylation of 2,3-disubstituted indoles with allylic acetates in water
IS  - 1
UR  - http://publicatio.bibl.u-szeged.hu/16703/
EP  - 62
JF  - NEW JOURNAL OF CHEMISTRY
N2  - Due to their biological activity, indoles and substituted indoles have attracted considerable attention from both synthetic and medicinal scientists. Much effort has been directed toward the development of methods for the functionalization of the indole nucleus. The protocol uses a catalytic amount of catalyzed platinum as a promoting agent, producing N-allylated indoles in considerable yields. Moreover, water, with its large heat capacity, is one of the most abundant molecules on earth. The use of water as a solvent may bring about many environmental benefits. Herein, we have demonstrated that the platinum-catalyzed selective N-allylation of 2,3-disubstituted indoles proceeds in water. This method provides a simple, convenient, and efficient way to afford a high yield of N-allylated indoles.
ER  -